Berberis aristata Roxb. ex DC. · Family: Berberidaceae · Root Extract · Berberine HCl 97%
The most studied natural ingredient for metabolic health — standardised to 97% Berberine Hydrochloride by HPLC from Berberis aristata (Indian Barberry / Daruharidra) roots. Trusted by supplement, nutraceutical, and pharma formulators worldwide. supply from GMP and ISO-certified facilities in India.
Actual Product
Berberis aristata · 97% Berberine HCl · Actual BatchA bright-yellow isoquinoline alkaloid — the metabolic-health cornerstone
Berberine is a quaternary isoquinoline alkaloid found in the roots, stems, and bark of several plants. SV Botanica produces it from Berberis aristata — known as Indian Barberry, Tree Turmeric, or Daruharidra in Ayurveda — whose roots carry one of the richest natural concentrations of berberine. The result is a vivid yellow, free-flowing powder standardised to 97% Berberine Hydrochloride by HPLC.
Berberine's signature mechanism is activation of AMP-activated protein kinase (AMPK), the body's master metabolic switch. Through this and related pathways it influences glucose uptake, lipid metabolism, and the gut microbiome — which is why it has become one of the most clinically researched natural ingredients in the blood-sugar, cholesterol, and metabolic-syndrome categories.
Our berberine is sourced from cultivated, non-irradiated raw material and verified GMO-free, with botanical identity and assay confirmed by HPLC against a reference profile. It is purified to a consistent yellow to yellowish-brown powder that passes 100% through a #40 mesh, ideal for capsules, tablets, and standardised nutraceutical blends.
We supply supplement brands, contract manufacturers, and Ayurvedic and pharma formulators across Europe, the USA, the Middle East, and Southeast Asia. New buyers can review our full herbal extract range or request a Certificate of Analysis and specification sheet before ordering.
The protoberberine alkaloid profile of Berberis aristata
The primary isoquinoline alkaloid, quantified by HPLC as Berberine HCl at ≥97%. Drives AMPK activation and the extract's metabolic activity.
A closely related protoberberine alkaloid contributing antimicrobial and metabolic activity; a typical companion marker in Berberis extracts.
Protoberberine alkaloid with documented lipid-modulating and antioxidant effects in preclinical research.
Minor protoberberine alkaloid present in the native root, part of the characteristic HPLC fingerprint.
A bisbenzylisoquinoline alkaloid of Berberis aristata studied for cardiovascular and immunomodulatory activity.
Bisbenzylisoquinoline alkaloid native to barberry root, complementing the protoberberine fraction.
Evidence from clinical trials, meta-analyses, and mechanistic research
Berberine activates AMPK and is studied for its effect on insulin sensitivity. Randomised trials have reported reductions in fasting glucose and HbA1c, which is the basis for its position in the blood-sugar supplement category. Berberine is a dietary ingredient and not a substitute for prescribed medication.
Ref: Yin J et al., 2008; MetabolismBerberine up-regulates the LDL receptor through an ERK-dependent pathway distinct from statins, lowering LDL cholesterol and triglycerides. Meta-analyses confirm consistent improvements in lipid panels.
Ref: Kong W et al., 2004; Nature MedicineBy targeting AMPK and adipocyte metabolism, berberine improves multiple components of metabolic syndrome — waist circumference, blood pressure, and insulin resistance — in clinical studies.
Ref: Hu Y et al., 2012; PhytomedicineBerberine has a long traditional use for digestive complaints and exerts antimicrobial and prebiotic-like effects, favourably reshaping gut microbiota composition — increasingly linked to its metabolic benefits.
Ref: Zhang X et al., 2012; PLoS ONEIn polycystic ovary syndrome, berberine has been shown to improve insulin resistance and lipid metabolism, making it a popular ingredient in women's metabolic and hormonal-support formulas.
Ref: Wei W et al., 2012; Eur J EndocrinolBerberine modulates inflammatory signalling (NF-κB) and reduces oxidative stress markers, supporting its broader role in cardiometabolic and healthy-ageing formulations.
Ref: Li Z et al., 2014; Mediators InflammBerberine is supplied as a dietary/nutraceutical ingredient. SV Botanica makes no therapeutic claims; finished-product claims and dosing are the brand owner's responsibility per destination-market regulations.
Select the right purity and form for your formulation requirement
| Grade | Berberine Content | Assay | Best For | Certifications |
|---|---|---|---|---|
| Berberine HCl 97% Standard | ≥97% Berberine HCl (anhydrous) | HPLC | Capsules, tablets, mainstream metabolic supplements | GMP, ISO, Halal, Kosher |
| Berberine HCl 98% Premium | ≥98% Berberine HCl (anhydrous) | HPLC | Pharmaceutical-grade and clinical-dose formulations | GMP, ISO, Halal, Kosher |
| Berberine HCl 90% Entry | ≥90% Berberine HCl | HPLC | Cost-sensitive blends and combination products | GMP, ISO, FSSAI |
| Berberis aristata Root Extract Whole-herb | 4:1 / 10:1 native or 5–10% berberine | HPLC / UV | Traditional Ayurvedic (Daruharidra) formulations | GMP, ISO, FSSAI |
| Dihydroberberine Enhanced | Reduced form, higher bioavailability | HPLC | Absorption-optimised, lower-dose products (on request) | GMP, ISO |
Current product specification on file: Berberine HCl 97% — Doc. SVB-PS-BA97-01 (Berberis aristata, roots; Berberine HCl ≥97.0% by HPLC). Berberine from Berberis aristata and Coptis chinensis source plants available; specify preferred botanical origin and grade at time of inquiry. Custom mesh sizes available for orders ≥100 kg.
Berberine Extract is bought in five forms. The standardised extract is the stocked item; granulated and dispersible grades are produced on request and raw botanical forms are sourced against a confirmed order.
| Form | What it is | Specification basis | Availability |
|---|---|---|---|
| Standardised extract powder | Berberis aristata root extract, dried and milled | NLT 97% berberine HCl (HPLC) | Stocked |
| Granulated (direct-compression) | Extract granulated for tablet lines | Same marker, declared on the granule | On request |
| Water-dispersible / soluble | Extract in a dispersible matrix for beverages, gummies and sachets | Marker declared on the matrix basis; carrier named | On request |
| Root powder (non-extracted) | Cleaned, dried Berberis aristata root, milled to mesh | Botanical identity by TLC; heavy metals and microbial panel | On enquiry, subject to lot; phytosanitary certificate usually required |
| Cut & sifted root | Dried root pieces, sifted to size | Identity, moisture, foreign matter | On enquiry; for tea, decoction and in-house extraction |
A marker percentage without its assay method is not a specification; ask for the method and the plant part on every quotation. Read Berberine Extract Buyer's Guide: Purity, Specs & Sourcing, Berberine Benefits: AMPK, Blood Sugar & Lipids and Berberine HCl Purity & HPLC Testing before comparing offers.
Full analytical profile — Berberine HCl 97% grade (per Product Specification SVB-PS-BA97-01)
| Parameter | Specification | Typical Result |
|---|---|---|
| Botanical Source | Berberis aristata Roxb. ex DC. | Conforms |
| Plant Family | Berberidaceae | — |
| Part Used | Roots | — |
| Identification (HPLC) | HPLC profile complies with reference, all major peaks | Complies |
| Marker Compound | Berberine Hydrochloride | — |
| Assay Method | HPLC (anhydrous basis) | — |
| Berberine HCl Content | NLT 97.0% w/w | 97.6% |
| Colour | Yellow to yellowish-brown | Conforms |
| Odour & Taste | Characteristic | Conforms |
| Texture | Free-flowing powder without lumps | Conforms |
| Particle Size | 100% through #40 mesh (USP <786>) | 100% |
| Water Content | NMT 12.0% w/w (USP <921>) | 8.4% |
| Residue on Ignition | NMT 0.1% w/w (USP <281>) | 0.06% |
| Heavy Metals (ICP-OES/MS) | Pb ≤1.0 · As ≤1.0 · Cd ≤1.0 · Hg ≤0.1 ppm | Complies |
| Total Aerobic Microbial Count | NMT 3,000 CFU/g | Complies |
| Total Yeast & Mould | NMT 100 CFU/g | Complies |
| Coliforms | Negative / 10 g | Absent |
| E. coli / Salmonella / S. aureus / P. aeruginosa | Absent | Absent |
| Cultivation / Sanitising | Cultivated · Non-irradiated | Conforms |
| GMO Status | GMO Free | Conforms |
| Shelf Life | 36 months from manufacture (sealed, <30°C, dry, dark) | — |
| Packaging | 25 kg HDPE drum with inner PE liner; multi-wall kraft bag option | — |
Specification per SV Botanica Product Specification SVB-PS-BA97-01 (Rev. 01). Typical results shown are representative of recent batches; a current batch-specific Certificate of Analysis, MSDS, and allergen/Non-GMO declarations are issued with every shipment. Specifications for 90%, 98%, and whole-root grades available on request.
From root to standardised alkaloid — traceable, tested, certified
Raw Material Sourcing: Berberis aristata roots are obtained from cultivated, authenticated material under Good Agricultural and Collection Practices (GACP). Botanical identity is confirmed by macroscopic, microscopic, and HPLC fingerprinting against a reference standard, ensuring the correct species and a consistent native alkaloid profile.
Manufacturing: Berberine is isolated and purified in GMP-certified, ISO-audited facilities using validated, controlled processes, then dried to a free-flowing powder. Each batch is released only after a full QC battery — HPLC assay for Berberine HCl, water content, residue on ignition, mesh-size verification, heavy-metals ICP-OES/MS, and a complete microbiological panel.
Documentation: Every shipment carries a batch-specific Certificate of Analysis (CoA), MSDS, Allergen Declaration, BSE/TSE-free statement, Non-GMO affidavit, and Country of Origin Certificate. Halal and Kosher certificates and a Phytosanitary Certificate for export are available on request. Buyers can request our specification sheet and CoA before placing an order.
Full compliance for global B2B supply
Key information for global product registration and labelling
Berberine is used in food supplements across several EU member states, declared as Berberis aristata root extract. Note that some markets (e.g. Italy) apply maximum-daily-intake limits for berberine — always verify the rules of the destination market. Labelling must comply with Regulation (EU) 1169/2011.
Berberine is marketed as a dietary ingredient under DSHEA (21 CFR Part 111), with no pre-market approval required for dietary supplements. Importer facility registration with the FDA is required. Structure-function claims are permissible with 30-day FDA notification and substantiation.
Berberis aristata (Daruharidra) is a classical Ayurvedic ingredient recognised under the Drugs and Cosmetics Act, and FSSAI-compliant for nutraceutical use under the FSS (Health Supplements, Nutraceuticals…) Regulations 2022. Widely accepted in the Middle East (Halal grades) and Southeast Asia, subject to local limits.
Deep-dive articles for formulators, buyers, and brand owners
Purity, CoA essentials, bioavailability and sourcing 97% Berberis aristata.
ScienceAMPK, blood glucose, lipids and PCOS — the human evidence behind the claims.
AnalyticsWhy method and basis matter, and what a complete berberine CoA must show.
RegulatoryEU per-market dose limits, US dietary-supplement status and India's framework.
MarketThe science behind the comparison and where berberine fits the market.
Frequently co-formulated with Berberine Extract in metabolic-health products
Technical and commercial questions answered by our ingredients team
Made at GMP-certified facilities, HPLC-tested, fully documented supply. 97% and 98% Berberine HCl grades available. Minimum order 25 kg. Samples available for qualified buyers.
Supplied as a bulk ingredient for further manufacture. Buyers are responsible for compliance with the regulations of their destination market. This product is not intended to diagnose, treat, cure or prevent any disease.
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