Every Resveratrol batch is tested by HPLC with specific trans-isomer quantification, heavy metals panel, and microbial safety verification. Nitrogen-flushed packaging prevents oxidative isomerisation during storage and transit.
HPLC certificates specifically report trans-Resveratrol content — not total resveratrol. Buyers receive the data they need to confirm biological activity, not just total polyphenol content.
Trans-Resveratrol isomerises to the inactive cis-form upon UV and oxygen exposure. All batches are packaged under nitrogen atmosphere to preserve trans-isomer integrity through shipping.
Polygonum cuspidatum root material is tested for pesticide residues (EU MRLs), lead, mercury, arsenic, cadmium, and microbial safety per USP standards before extraction.
COA with trans-isomer content, MSDS, Certificate of Origin, and Phytosanitary Certificate provided with every shipment. Halal/Kosher certificates on request.
The resveratrol supplement market has significant quality variation because most buyers don't look past the headline purity figure. A COA stating "98% resveratrol" tells you almost nothing about the product's therapeutic value unless it specifies the trans to cis isomer ratio. Understanding the four key dimensions below — isomeric form, botanical source, grade, and bioavailability enhancement — allows buyers to specify exactly what they need and verify that they received it.
The naturally occurring, biologically active geometric isomer. Its planar molecular structure allows direct binding to SIRT1's allosteric site and AMPK activation. All clinical studies use this form. COA must show ≥98% trans-Resveratrol by HPLC — not "total resveratrol." Light and oxygen convert it to the cis form, so nitrogen packaging is essential. This is the only form SV Botanica supplies at the 98–99% grade.
The geometrically isomeric form produced by UV exposure and oxidation of trans-Resveratrol. The bent molecular shape prevents SIRT1 binding and renders the compound biologically inactive at physiological doses. Any resveratrol stored improperly or in transparent packaging will accumulate cis-form. Buyers receiving a COA for "total resveratrol" without isomeric specification should request a separate trans-isomer quantification or reject the material.
Japanese knotweed root is the dominant commercial source for high-purity trans-Resveratrol. Native root concentrations of 10–15% dry weight make extraction economically viable for pharmaceutical grades (98–99%). The resulting extract is white to off-white crystalline powder. It is the preferred source for supplement brands prioritising purity and cost efficiency. "Natural" label claims are supportable — Polygonum cuspidatum is a plant-derived botanical source.
Oral bioavailability of crystalline trans-Resveratrol is approximately 1% due to rapid phase II metabolism (sulphation and glucuronidation) in the intestinal wall. Piperine (5–10mg from black pepper extract) inhibits these conjugating enzymes and has been shown to increase resveratrol AUC by up to 229% in controlled studies. Micronised resveratrol particles improve dissolution rate. For high-dose formulations (500mg+), liposomal encapsulation is increasingly used to improve systemic delivery.