Every Quercetin batch is tested by HPLC for flavonol content, absence of rutin and isoquercetin impurities, heavy metals panel, and microbial safety — with COA explicitly reporting quercetin content, not total flavonoids.
COA reports specific quercetin content by HPLC, not total flavonoid content. Rutin and isoquercetin (quercetin glycosides) have different bioavailability profiles and must be distinguished from the aglycone/dihydrate.
Japanese pagoda tree flower buds contain 15–25% quercetin by dry weight — the richest commercial plant source. Consistent botanical identity verified by TLC and HPLC fingerprinting on each raw material batch.
Sophora japonica raw material is tested for pesticide residues (EU MRLs), lead (NMT 0.5 ppm), mercury, arsenic, cadmium, and microbial contamination to USP and BP pharmacopoeia standards.
COA, MSDS, Certificate of Origin, Phytosanitary Certificate provided with every shipment. Halal and Kosher certificates available on request for specific markets.
The quercetin market has expanded dramatically post-2020, partly driven by immune supplement demand and partly by growing consumer awareness of senolytic protocols. But there is significant confusion in the market between quercetin forms (aglycone vs dihydrate vs glycosides vs phytosome), and between quercetin purity specs and total flavonoid content. This guide helps formulators specify the right grade and build effective quercetin-containing products.
The workhorse ingredient for most supplement manufacturers. Yellow crystalline powder, excellent shelf stability, good flow for capsule filling. The "dihydrate" refers to 2 water molecules of crystallisation — biologically identical to aglycone once metabolised. Specify HPLC-confirmed ≥98% quercetin dihydrate on your COA — not "total flavonoids."
Quercetin complexed with phosphatidylcholine (soy or sunflower lecithin). The phospholipid matrix dramatically improves mucosal absorption, with studies showing up to 20× higher Cmax vs standard quercetin. The choice for premium anti-aging and longevity formulations where bioavailability is the primary differentiator. Higher cost per gram but lower effective dose required.
The most popular quercetin combination in immune and anti-inflammatory supplement formulations. Bromelain (a proteolytic enzyme from pineapple) enhances quercetin absorption and adds independent anti-inflammatory activity via different pathways (serine protease inhibition vs NF-κB inhibition). Standard ratio: quercetin 500mg + bromelain 500 GDU per serving. SV Botanica can supply both separately or as a pre-blended combination.
The most-studied senolytic protocol combines quercetin with dasatinib (a prescription drug) in short "pulse" cycles — typically 1,000mg quercetin + 100mg dasatinib for 3 consecutive days, then a 2–4 week rest period. Quercetin-only supplements for longevity positioning typically use 500–1,000mg per dose. The key formulation consideration is bioavailability — phytosome form is preferred for senolytic protocols.