Two Markers, Two Behaviours

Seeram, Lee and Heber (Clinica Chimica Acta, 2004) detected ellagic acid in plasma after volunteers drank pomegranate juice rich in punicalagins. The authors noted that it may come from ellagitannin hydrolysis in the body.

Expect the Markers to Move

Because punicalagins can hydrolyse to ellagic acid, heat, acid and long storage in water can shift the balance between them. A drink specified on punicalagins may test lower after pasteurisation and shelf life, and higher in free ellagic acid. Measure the label marker in the finished product at the end of shelf life.

Capsules and Tablets

For capsules, the 40% ellagic acid grade (HPLC) or the 40% punicalagins grade (UV) is usual. Both are fine powders between 40 and 80 mesh. Dark tannin-rich powders can stain, so opaque shells help.

Drinks, Shots and Sachets

Use the water-soluble grade, which is spray-dried with at least 30% polyphenols and at least 90% water solubility. Expect astringency at higher doses. Sweetness, acidity and red-fruit flavours balance it.

Tannins bind proteins, so protein drinks can turn hazy. Test in the full recipe.

Peel or Fruit?

Pomegranate extracts can be made from peel, aril, seed or the whole fruit, and the marker profile differs. Ask which part was used and keep it on the specification. Our peel vs fruit article explains why it matters.

Choosing the Grade

GradeTypical use
40% ellagic acid (HPLC)Capsules, tablets, skin-focused supplements
40% punicalagins (UV)Antioxidant capsules
Polyphenols 30% (UV, as gallic acid)General blends
Water-soluble gradeDrinks, shots, sachets, effervescents
Full-spectrum or organic (on request)Clean-label and organic lines

Grades are on the pomegranate extract page. For assay methods see ellagic acid: HPLC vs UV.