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Quick Specs
FormTrans-Pterostilbene
Purity≥99% (HPLC)
Bioavailability~80% oral
Shelf life24 months
MOQ1 kg (sample); 5 kg (commercial)
Nutraceuticals

Pterostilbene

Trans-Pterostilbene ≥99% Purity ~80% Bioavailability Trans-Isomer Confirmed
A methylated analogue of resveratrol with a markedly higher oral bioavailability (~80% against ~1%), supplied at ≥99% by HPLC with the trans isomer confirmed.
Pterostilbene (trans-3,5-dimethoxy-4'-hydroxystilbene) is a naturally occurring stilbenoid structurally analogous to resveratrol, differing by the substitution of two hydroxyl groups with methoxy groups on the A-ring. This seemingly small chemical modification has dramatic pharmacokinetic consequences: while resveratrol has ~1% oral bioavailability due to rapid phase-II conjugation, pterostilbene achieves ~80% oral bioavailability because its methoxy groups block the primary conjugation sites, allowing far greater systemic absorption. Found naturally in blueberries, grapes, and the heartwood of Pterocarpus marsupium (Indian kino tree), commercial supply is primarily via chemical synthesis or semi-synthesis from resveratrol, yielding >99% purity material. CAS 537-42-8.

Pterostilbene differs from resveratrol chiefly in its pharmacokinetics: the two methoxy groups block the principal phase-II conjugation sites, which is why oral bioavailability is far higher. It additionally acts as a PPARα agonist (relevant to lipid metabolism and fatty acid oxidation), crosses the blood-brain barrier more efficiently than resveratrol, and demonstrates COMT inhibition that supports dopaminergic neurotransmission. SV Botanica supplies ≥99% pterostilbene from certified manufacturers at GMP/ISO-certified facilities, batch-tested by HPLC. The longevity supplement category is the primary growth driver; pterostilbene is increasingly used alongside NMN (nicotinamide mononucleotide) and quercetin in premium anti-aging stacks.
Available specifications
Pterostilbene 99%
HPLC-verified, synthetic/semi-synthetic
Pterostilbene 98%
Standard grade
Pterostilbene + Resveratrol
Pre-blended dual-stilbenoid grade
Trans-Pterostilbene
Trans geometric isomer confirmed on CoA
  • Photoisomerisation control — the trans isomer converts on light exposure, which is the governing handling constraint. Opaque, light-protected packaging is standard and should be carried through into the finished pack where the format allows.
  • Isomer confirmation on CoA — a grade is available with the trans geometric isomer explicitly confirmed, which matters where the finished-product specification is written against the trans form specifically.
  • Solubility handling — sparingly soluble in water; ethanol, DMSO and PEG 400 dissolve it. PEG 400 in particular is a common route for softgel and liquid formats.
  • Resveratrol blend — a pre-blended combination grade supplied where a formulator wants both stilbenoids in a single specified ratio rather than blending in-house.
  • Capsule and softgel formats — the 60–100 mesh powder blends predictably; the off-white colour does not carry a pigment constraint into the finished dose form.
  • Grade selection — the ≥99% HPLC grade is the primary specification; the ≥98% standard grade is specified where the wider assay window is acceptable.
  • Packaging — 1 kg nitrogen-flushed foil bags and 5 kg and 25 kg fibre drums with aluminium inner liner and desiccant, all opaque to prevent photoisomerisation. Custom pack sizes available for research and private-label batches.
  • Documentation — each batch ships with a CoA covering assay by HPLC against the ≥99% specification, isomer confirmation where specified, heavy metals at NMT 10 ppm with lead at NMT 0.5 ppm, moisture at NMT 0.5% and microbial limits.
Supplement capsules and softgels
Longevity-category formulations
Stilbenoid combination products
Liquid and PEG-carrier systems
Research and clinical-supply quantities
Private-label and contract manufacture
Cosmetic antioxidant systems
Powder blends and stick packs
Common namePterostilbene (trans-Pterostilbene)
IUPAC name(E)-4-(3,5-Dimethoxystyryl)phenol
Synonymstrans-3,5-Dimethoxy-4'-hydroxystilbene; 3,5-Dimethoxy-4-hydroxystilbene; Pterostilben
CAS number537-42-8
Molecular formulaC₁₆H₁₆O₃
Molecular weight256.30 g/mol
AppearanceWhite to off-white crystalline powder
Assay (HPLC)≥99.0% trans-Pterostilbene
Botanical/natural sourceBlueberries (Vaccinium spp.), Pterocarpus marsupium heartwood (Indian kino tree)
Commercial productionSynthetic or semi-synthetic methylation of resveratrol
SolubilitySparingly soluble in water; soluble in ethanol (~15 mg/mL), DMSO, PEG 400; practically insoluble in hexane
LogP (lipophilicity)3.97 (more lipophilic than resveratrol at 2.86)
Melting point89–90°C
Oral bioavailability~80% (vs ~1% for resveratrol)
Plasma half-life~105 minutes (total; free + metabolites)
Moisture contentNMT 0.5%
Heavy metalsNMT 10 ppm total; Lead NMT 0.5 ppm
Microbial limitsTotal aerobic count NMT 10³ CFU/g; Absence of Salmonella, E. coli
Shelf life24 months in original sealed packaging, protected from light
StorageBelow 25°C, away from light, heat, and moisture; store in opaque containers
1 kg aluminium foil bags (nitrogen-flushed, light-protected)
5 kg and 25 kg fibre drums with aluminium inner liner and desiccant
Light-protected, opaque packaging to prevent photoisomerisation
Custom pack sizes for research and private-label batches
Quality Assurance

≥99% Trans-Isomer Confirmed. HPLC-Verified.

Every Pterostilbene batch is tested by HPLC with specific trans-pterostilbene quantification and geometric isomer confirmation — not total stilbene content. Light-protected, nitrogen-packaged to prevent isomerisation during transit.

01

Trans-isomer HPLC verification

COA explicitly confirms trans-pterostilbene content; cis-pterostilbene (inactive form) is identified and reported separately — not bundled into a "total stilbene" figure that obscures the biologically active fraction.

02

Nitrogen-flushed packaging

Light and oxidation convert trans to cis isomer. All pterostilbene is shipped in opaque, nitrogen-flushed aluminium foil packaging to preserve geometric isomer integrity throughout transit and storage.

03

Heavy metals & purity panel

Lead, mercury, arsenic, cadmium, residual solvents (ICH Q3C), and microbial testing per USP standards. Full panel reported on COA with every batch — not just assay and appearance.

04

Export documentation

COA, MSDS, Certificate of Origin, and Phytosanitary Certificate with every shipment. GMP and ISO facility certification documents available digitally before shipment.

Formulation Intelligence

Pterostilbene vs Resveratrol: The Bioavailability Advantage Explained

The supplement industry's obsession with resveratrol is well-documented — but formulators working in longevity and cognitive enhancement increasingly reach for pterostilbene because its pharmacokinetics solve resveratrol's fundamental limitation. Understanding the structural chemistry behind this difference allows buyers to make informed specifications and communicate the science convincingly on product labels.

Superior Bioavailability

Pterostilbene

CAS: 537-42-8

~80% oral bioavailability due to methoxy group protection of conjugation sites. Once-daily dosing supported by 105-minute half-life. Effective at 50–150mg. Better blood-brain barrier penetration due to higher lipophilicity (logP 3.97). PPARα agonist and COMT inhibitor — activities not shared by resveratrol.

The preferred choice when systemic delivery and CNS effects are the formulation goal.
Lower Bioavailability

Resveratrol

CAS: 501-36-0

~1% oral bioavailability (rapid sulphation at hydroxyl groups at the 3- and 5-positions of the A-ring). Requires 500–1,000mg doses for comparable systemic effects. Strong clinical literature and consumer brand recognition. Lower cost per gram than pterostilbene.

Best for label recognition and when combined with piperine for bioavailability enhancement.
PPARα Agonist

Lipid & Metabolic Effects

Unique to pterostilbene — not seen with resveratrol

Pterostilbene's methoxy groups increase lipophilicity and enable PPARα receptor binding. PPARα activation promotes fatty acid oxidation, reduces triglycerides, and increases HDL. Supplied for the cardiovascular-support and longevity supplement categories; the claim position is set by the finished-product manufacturer and by the destination market.

Unique to pterostilbene — not seen with resveratrol.
Cognitive Stack

Blood-Brain Barrier Penetration

logP 3.97 vs 2.86 for resveratrol

Higher lipophilicity means pterostilbene crosses the blood-brain barrier more effectively than resveratrol. Animal studies show improved spatial memory, reduced hippocampal oxidative stress, and protection against amyloid pathology. Human cognitive studies in progress. Positioning: nootropic and healthy aging cognitive formulations.

50–100mg doses shown effective in preclinical models.
Buyer FAQ

Frequently Asked Questions

An HPLC-verified grade at ≥99% by synthetic or semi-synthetic route as the primary specification, a standard grade at ≥98%, a pre-blended dual-stilbenoid grade with resveratrol, and a grade with the trans geometric isomer explicitly confirmed on the certificate of analysis.
The trans isomer photoisomerises on light exposure, which is the governing handling constraint. Material ships in opaque, light-protected packaging, and where the finished format allows, that protection should be carried through into the retail pack. Shelf life of 24 months assumes sealed, cool, dry, dark storage.
Yes. A grade is available with the trans geometric isomer explicitly confirmed. This matters where your finished-product specification is written against the trans form specifically rather than against total pterostilbene.
It is sparingly soluble in water and soluble in ethanol, DMSO and PEG 400. PEG 400 in particular is a common carrier route for softgel and liquid formats. For dry formats the 60–100 mesh powder blends directly.
Assay by HPLC against the ≥99% specification, isomer confirmation where that grade is specified, heavy metals at NMT 10 ppm with lead at NMT 0.5 ppm, moisture at NMT 0.5%, and microbial limits.
White to off-white fine powder at 60–100 mesh. Moisture NMT 0.5%. Shelf life 24 months sealed, cool, dry and protected from light. The off-white colour does not carry a pigment constraint into the finished dose form.
1 kg nitrogen-flushed foil bags, and 5 kg and 25 kg fibre drums with an aluminium inner liner and desiccant — all opaque, to prevent photoisomerisation. Custom pack sizes are available for research and private-label batches.
Facility certification documents and the Certificate of Analysis for the batch. Halal and Kosher certificates are available on request. Material is made at GMP- and ISO-certified facilities.
Against your specification and volume. Grade, isomer confirmation, pack size and whether a blend format is required all move the price, so send a specification sheet with your intended format.
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Supplied as a bulk ingredient for further manufacture. Buyers are responsible for compliance with the regulations of their destination market. This product is not intended to diagnose, treat, cure or prevent any disease.