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Quick Specs
CAS56-85-9
Purity≥99.0% (pharma); ≥98.5% (food)
SourceBacterial fermentation
Shelf life24 months
MOQ1 kg (sample); 25 kg (commercial)
Nutraceuticals

L-Glutamine

Conditionally Essential Amino Acid Fermentation-Derived Pharma & Food Grade CAS 56-85-9
The most abundant amino acid in the body — yet the first to be depleted under stress. L-Glutamine is indispensable for gut barrier integrity, immune function, and rapid cellular repair in sports, clinical, and medical nutrition applications.
L-Glutamine occupies a unique position in clinical and sports nutrition: it is the primary fuel for intestinal enterocytes and immune cells, the most abundant amino acid in human plasma and muscle, and the first to fall in response to physiological stress. It is specified into both the sports nutrition and clinical nutrition segments, which have different grade and documentation requirements.

SV Botanica supplies pharmaceutical-grade L-Glutamine (≥99.0%, USP/BP compliant) for clinical nutrition, medical foods, and regulated supplements, and food-grade (≥98.5%) for sports and general supplement applications — both fermentation-derived, made at GMP-certified facilities, with full traceability documentation.
Available specifications
Pharma Grade ≥99%
USP/BP compendial grade — supplements, medical foods
Food Grade ≥98.5%
Food-grade fermentation — sports nutrition
Instant-Dissolve Powder
Fine mesh for rapid mixing in beverages
Bulk Powder / Granule
25 kg bags — sports nutrition manufacturing
  • Limited water solubility — at 3.6 g/100 mL (20°C) glutamine is markedly less soluble than most amino acids in the range. High-concentration liquids will not carry it; the instant-dissolve grade exists to improve dispersion rate, not to raise the solubility ceiling.
  • Insoluble in alcohol — relevant when formulating tinctures or alcohol-based liquids, where an aqueous or aqueous-alcohol system is required instead.
  • Grade selection — the ≥99.0% USP/BP grade is specified where a compendial reference is required by the finished-product monograph or customer specification; the ≥98.5% food grade covers sports nutrition.
  • Instant-dissolve format — a fine-mesh grade intended for rapid mixing in beverages and shakers, where dispersion speed rather than total solubility is the constraint.
  • Powder blends and tubs — the 40–80 mesh grade blends uniformly with common carriers and flows well in tub and sachet filling.
  • Storage — nitrogen-flushed, moisture-barrier sealed packaging with moisture specified at NMT 0.5% in the pharmaceutical grade; 24-month shelf life sealed, cool and dry.
  • Manufacturing scale — 25 kg multi-layer kraft bags with an inner PE liner in food or pharma grade, and 5 kg aluminium foil bags for smaller commercial orders.
  • Documentation — each batch ships with a CoA covering assay against the stated grade, heavy metals at NMT 10 ppm with lead at NMT 0.5 ppm, moisture and microbial limits, plus a fermentation-route declaration.
Sports nutrition powders
Clinical and medical nutrition
Capsule and tablet supplements
Instant and shaker formats
Gut-health category formulations
Powder blends and stick packs
Food fortification
Private-label and contract manufacture
Common nameL-Glutamine
SynonymsGln; Q; 2-Aminoglutaramic acid; Glutamine
CAS number56-85-9
Molecular formulaC₅H₁₀N₂O₃
Molecular weight146.15 g/mol
AppearanceWhite crystalline powder, odourless, tasteless
Assay (pharma grade)≥99.0% (HPLC, USP/BP)
Assay (food grade)≥98.5% (HPLC)
Specific rotation[α]D²⁰ = +6.1° to +6.7° (c=2, 6N HCl)
pH (5% aqueous solution)5.0–6.5
Melting point185°C (decomposes)
Solubility in water3.6 g/100 mL at 20°C; insoluble in ethanol
Loss on dryingNMT 0.5%
Residue on ignitionNMT 0.1%
Heavy metals (total)NMT 10 ppm
LeadNMT 0.5 ppm
ArsenicNMT 0.5 ppm
Microbial limitsTPC NMT 10³ CFU/g; absence of Salmonella, E. coli
Source / productionBacterial fermentation (Corynebacterium glutamicum); non-animal
Shelf life24 months (<25°C, dry, sealed, away from moisture)
25 kg multi-layer kraft bags with inner PE liner (food/pharma grade)
5 kg aluminium foil bags for smaller commercial orders
Nitrogen-flushed, moisture-barrier sealed packaging
Custom packaging and private label available
Quality Assurance

Fermentation-Derived. Pharmaceutical Purity. Batch-Tested.

Every batch tested by HPLC for ≥99% assay, specific rotation, heavy metals, microbial limits, and residual solvents. GMP-certified fermentation source with full traceability documentation.

01

HPLC purity verification

Assay ≥99.0% (pharma) / ≥98.5% (food) by HPLC. Specific rotation [α]D²⁰ = +6.1° to +6.7° confirms L-isomer identity. Residual solvents and related amino acid impurities profiled per USP.

02

Fermentation source traceability

Bacterial fermentation (Corynebacterium glutamicum). Non-animal, non-GMO certification available. Fermentation batch records provided. No risk of TSE/BSE contamination from animal-derived sources.

03

Microbial and heavy metal testing

TPC NMT 10³ CFU/g; absence of Salmonella, E. coli, Staphylococcus aureus. Lead NMT 0.5 ppm; Arsenic NMT 0.5 ppm; Mercury NMT 0.1 ppm. All tested per USP/EP methods.

04

Export documentation

Full COA, MSDS, Certificate of Origin. USP/BP analytical certificates. FSSAI compliance for food applications. Halal/Kosher certificates on request. Digital documentation before shipment.

Formulation Intelligence

L-Glutamine Buyer's Guide: Pharma vs Food Grade, Clinical vs Sports Applications & Formulation Pitfalls

L-Glutamine is simultaneously a clinical nutrition staple (mandated in ICU parenteral protocols) and the world's top-selling sports supplement amino acid. Understanding the grade, application, and formulation stability requirements prevents costly specification errors.

Pharma Grade

USP/BP ≥99.0%

CAS 56-85-9 · Parenteral & medical food grade

Specified for parenteral nutrition, medical foods and research formulations. Tighter limits on heavy metals (Pb NMT 0.5 ppm), endotoxins, residual solvents. Full USP/BP COA with each batch. Fermentation-derived. Compliant with ESPEN and ASPEN clinical nutrition guidelines.

Best for: Clinical nutrition, medical foods, parenteral formulations, regulatory submissions.
Food Grade

≥98.5% HPLC

Food-grade fermentation · Sports & general supplements

Suitable for sports recovery supplements, pre/post-workout formulas, general health supplements, and food fortification. Same fermentation source, slightly relaxed analytical limits. Correct specification for the vast majority of commercial supplement applications. Significantly lower cost than pharma grade.

Best for: Sports supplements, general health formulations, food fortification.
Key Application

Clinical Nutrition vs Sports

Very different dose ranges and endpoints

ICU/clinical: 0.2–0.4 g/kg/day IV glutamine (ESPEN guideline). Sports recovery: 5–10g post-exercise. Gut health: 5–15g/day orally. Both are well-supported by clinical evidence. The two segments differ in grade, documentation and specification, so confirm which your finished product is written against.

Note: the compendial grade is normally required for clinical nutrition formats.
Formulation Alert

Stability Pitfalls

Glutamine is moisture-sensitive and hydrolyses in solution

Glutamine hydrolyses to glutamic acid in aqueous solution, especially at acidic pH and elevated temperature. For powders: moisture barrier packaging, desiccants, NMT 0.5% moisture at manufacture. For ready-to-drink beverages: specify alanyl-L-glutamine dipeptide (Ala-Gln) which is water-stable. Do not blend with reactive reducing sugars in hot processing.

Note: Powder blends are stable; RTD beverages require the dipeptide form for label-claim integrity.
Buyer FAQ

Frequently Asked Questions

A pharmaceutical grade at ≥99.0% against USP/BP for supplements and medical foods, a food grade at ≥98.5% for sports nutrition, an instant-dissolve fine-mesh grade for beverages, and bulk powder or granule in 25 kg for manufacturing. All are fermentation-derived.
It is only slightly soluble in water at 3.6 g/100 mL at 20°C — markedly less than most amino acids in this range — and insoluble in alcohol. High-concentration liquids will not carry it. The instant-dissolve grade improves how quickly it disperses, but does not raise the solubility ceiling.
Rapid mixing in beverages and shaker formats, where dispersion speed rather than total solubility is the constraint. It is a finer mesh cut of the same material.
Assay against the stated grade, heavy metals at NMT 10 ppm with lead at NMT 0.5 ppm, moisture at NMT 0.5% for the pharmaceutical grade, microbial limits, and a fermentation-route declaration.
Odourless white crystalline powder at 40–80 mesh. Moisture NMT 0.5% in the pharmaceutical grade. Shelf life 24 months in cool, dry, sealed storage.
Where a finished-product monograph or your own specification calls for a USP/BP reference, typically supplements and medical foods. The food grade at ≥98.5% covers sports nutrition applications.
The 40–80 mesh grade blends uniformly with common carriers and flows well in tub and sachet filling. Material ships nitrogen-flushed with a moisture barrier.
25 kg multi-layer kraft bags with an inner PE liner in food or pharma grade, and 5 kg aluminium foil bags for smaller commercial orders. Custom packaging and private label are available.
Against your specification and volume. Grade, mesh cut and pack size all move the price.
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Supplied as a bulk ingredient for further manufacture. Buyers are responsible for compliance with the regulations of their destination market. This product is not intended to diagnose, treat, cure or prevent any disease.