Sourced from GMP · ISO · Halal · Kosher certified facilities · FSSAI & APEDA registered exporter 📞 +91 8767675175 ✉ info@svbotanica.com
Home›Products›Nutraceuticals›L-Glutamine
Nutraceuticals
Request a Quote Request Free Sample WhatsApp Enquiry
Quick Specs
CAS56-85-9
Purity≥99.0% (pharma); ≥98.5% (food)
SourceBacterial fermentation
Shelf life24 months
MOQ1 kg (sample); 25 kg (commercial)
Nutraceuticals

L-Glutamine

Conditionally Essential Amino Acid Fermentation-Derived Pharma & Food Grade CAS 56-85-9
The most abundant amino acid in the body — yet the first to be depleted under stress. L-Glutamine is indispensable for gut barrier integrity, immune function, and rapid cellular repair in sports, clinical, and medical nutrition applications.
L-Glutamine occupies a unique position in clinical and sports nutrition: it is the primary fuel for intestinal enterocytes and immune cells, the most abundant amino acid in human plasma and muscle, and the first to fall in response to physiological stress. During critical illness, major surgery, intense exercise, or cancer treatment, plasma glutamine can drop 20–50% — directly impairing gut barrier function and immune competence.

SV Botanica supplies pharmaceutical-grade L-Glutamine (≥99.0%, USP/BP compliant) for clinical nutrition, medical foods, and regulated supplements, and food-grade (≥98.5%) for sports and general supplement applications — both fermentation-derived, GMP-certified, with full traceability documentation.
Available specifications
    Quality Assurance

    Fermentation-Derived. Pharmaceutical Purity. Batch-Tested.

    Every batch tested by HPLC for ≥99% assay, specific rotation, heavy metals, microbial limits, and residual solvents. GMP-certified fermentation source with full traceability documentation.

    01

    HPLC purity verification

    Assay ≥99.0% (pharma) / ≥98.5% (food) by HPLC. Specific rotation [α]D²⁰ = +6.1° to +6.7° confirms L-isomer identity. Residual solvents and related amino acid impurities profiled per USP.

    02

    Fermentation source traceability

    Bacterial fermentation (Corynebacterium glutamicum). Non-animal, non-GMO certification available. Fermentation batch records provided. No risk of TSE/BSE contamination from animal-derived sources.

    03

    Microbial and heavy metal testing

    TPC NMT 10³ CFU/g; absence of Salmonella, E. coli, Staphylococcus aureus. Lead NMT 0.5 ppm; Arsenic NMT 0.5 ppm; Mercury NMT 0.1 ppm. All tested per USP/EP methods.

    04

    Export documentation

    Full COA, MSDS, Certificate of Origin. USP/BP analytical certificates. FSSAI compliance for food applications. Halal/Kosher certificates on request. Digital documentation before shipment.

    Formulation Intelligence

    L-Glutamine Buyer's Guide: Pharma vs Food Grade, Clinical vs Sports Applications & Formulation Pitfalls

    L-Glutamine is simultaneously a clinical nutrition staple (mandated in ICU parenteral protocols) and the world's top-selling sports supplement amino acid. Understanding the grade, application, and formulation stability requirements prevents costly specification errors.

    Pharma Grade

    USP/BP ≥99.0%

    CAS 56-85-9 · Parenteral & medical food grade

    Required for ICU parenteral nutrition, medical foods, and clinical trial formulations. Tighter limits on heavy metals (Pb NMT 0.5 ppm), endotoxins, residual solvents. Full USP/BP COA with each batch. Fermentation-derived. Compliant with ESPEN and ASPEN clinical nutrition guidelines.

    Best for: Clinical nutrition, medical foods, parenteral formulations, regulatory submissions.
    Food Grade

    ≥98.5% HPLC

    Food-grade fermentation · Sports & general supplements

    Suitable for sports recovery supplements, pre/post-workout formulas, general health supplements, and food fortification. Same fermentation source, slightly relaxed analytical limits. Correct specification for the vast majority of commercial supplement applications. Significantly lower cost than pharma grade.

    Best for: Sports supplements, general health formulations, food fortification.
    Key Application

    Clinical Nutrition vs Sports

    Very different dose ranges and endpoints

    ICU/clinical: 0.2–0.4 g/kg/day IV glutamine (ESPEN guideline). Sports recovery: 5–10g post-exercise. Gut health: 5–15g/day orally. Both are well-supported by clinical evidence, but the patient population, route of administration, and endpoint differ entirely. Do not conflate sports efficacy data with clinical nutrition evidence.

    Note: Evidence base is strongest in ICU and GI clinical nutrition; sports evidence is supportive.
    Formulation Alert

    Stability Pitfalls

    Glutamine is moisture-sensitive and hydrolyses in solution

    Glutamine hydrolyses to glutamic acid in aqueous solution, especially at acidic pH and elevated temperature. For powders: moisture barrier packaging, desiccants, NMT 0.5% moisture at manufacture. For ready-to-drink beverages: specify alanyl-L-glutamine dipeptide (Ala-Gln) which is water-stable. Do not blend with reactive reducing sugars in hot processing.

    Note: Powder blends are stable; RTD beverages require the dipeptide form for label-claim integrity.
    Buyer FAQ

    Frequently Asked Questions

    Glutamine is classified conditionally essential because healthy adults synthesise sufficient amounts from other amino acids. However, during physiological stress — critical illness, major surgery, burns, sepsis, intense endurance training, or cancer treatment — demand exceeds synthetic capacity and plasma glutamine falls 20–50%. This depletion directly impairs gut barrier function and immune cell proliferation, both of which are glutamine-dependent. ESPEN clinical nutrition guidelines recommend 0.2–0.4 g/kg/day IV glutamine in ICU patients. For athletes, 5–10g post-exercise is the studied dose range.
    Intestinal enterocytes depend on glutamine as their primary oxidative fuel source — more so than glucose. Glutamine maintains tight junction protein expression (occludin, claudin-3, ZO-1), prevents paracellular permeability, stimulates intestinal mucus production, and drives enterocyte proliferation. Clinical trials show 0.3–0.5 g/kg/day supplementation significantly reduces plasma endotoxin, zonulin (permeability marker), and intestinal fatty acid binding protein (i-FABP) in ICU patients. This makes glutamine the cornerstone amino acid in gut-directed clinical nutrition.
    Both. In healthy athletes, prolonged intense exercise (>90 minutes) reduces plasma glutamine 20–30%, correlating with post-exercise immune suppression. Glutamine supplementation: (1) accelerates muscle glycogen resynthesis by providing gluconeogenic substrate; (2) reduces post-exercise IL-6 and CRP; (3) maintains secretory IgA in saliva — the primary mucosal immune defence. Effective dose in athletes: 5–10g immediately post-exercise. Effect size is largest in high-volume training phases.
    Pharmaceutical grade (≥99.0% HPLC, USP/BP compliant): required for medical foods, parenteral nutrition, clinical trials, and regulated health claim products. Food grade (≥98.5% HPLC): suitable for sports supplements, general health supplements, food fortification. Both are produced by bacterial fermentation. The specification difference is analytical stringency — pharmaceutical grade has tighter limits on heavy metals, residual solvents, and endotoxins. For consumer supplements, food grade is appropriate. For medical nutrition or clinical applications, specify pharma grade with USP/BP COA.
    L-Glutamine is hygroscopic and hydrolyses to glutamic acid and ammonia under heat and moisture. Critical formulation rules: (1) keep moisture below 0.5% — use desiccants and moisture-barrier packaging; (2) avoid temperatures >40°C; (3) do not combine with reactive aldehydes (Maillard reaction); (4) for RTD beverages, use alanyl-L-glutamine dipeptide (Ala-Gln) which is stable in solution; (5) shelf life 24 months at <25°C, sealed.
    You May Also Need