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Quick Specs
CAS74-79-3 (free base)
Purity≥99.5% (free base); ≥99.0% (HCl)
SourceBacterial fermentation
Shelf life24 months
MOQ1 kg (sample); 25 kg (commercial)
Nutraceuticals

L-Arginine

Free Base ≥99.5% Free Base & HCl Salt Fermentation-Derived CAS 74-79-3
L-arginine free base at ≥99.5% and the hydrochloride salt at ≥99.0%, with food and USP/BP compendial grades, for beverage, sports, clinical and powder-blend formats.
L-arginine is a semi-essential amino acid supplied as the free base or as the hydrochloride salt. The salt form is chosen where an aqueous system needs more arginine in solution than the free base can carry: the free base dissolves at 15 g/100 mL at 20°C, and the salt is markedly more soluble. Note the salt contributes chloride and has a different assay basis, so a weight-for-weight substitution changes the delivered arginine content. It is specified across the sports, cardiovascular-category, clinical-nutrition and wound-care formulation segments.

SV Botanica supplies pharmaceutical-grade L-Arginine free base (≥99.5%, alkaline pH, ideal for tablets and capsules) and L-Arginine HCl (≥99.0%, highly water-soluble, ideal for beverages and RTD products) — both fermentation-derived, USP/BP compliant, made at GMP-certified facilities.
Available specifications
L-Arginine Free Base ≥99.5%
Pharma grade — capsules, tablets, powder blends
L-Arginine HCl ≥99.0%
Water-soluble salt — beverages, ready-to-mix
Food Grade ≥98.5%
Sports nutrition and food fortification
Pharmaceutical Grade
USP/BP compendial grade — clinical formats
  • Free base versus HCl salt — the salt is chosen for aqueous systems where the free base cannot carry at the required concentration. Note the salt contributes chloride and the assay basis differs, so a straight weight-for-weight substitution changes the delivered arginine content.
  • Beverage and ready-to-mix formats — the HCl salt is the standard specification here. The free base at 15 g/100 mL (20°C) is adequate for many systems but is the limiting factor in high-concentration liquids.
  • Compendial grade — the USP/BP grade is specified where a finished-product monograph or a customer specification requires a compendial reference, typically in clinical and medical-nutrition formats.
  • Powder blends and stick packs — the 40–80 mesh grade blends uniformly with common carriers and flows well in sachet filling.
  • Moisture specification — NMT 0.5% for the free base and NMT 1.0% for the HCl salt. Material ships nitrogen-flushed and sealed for stability.
  • Manufacturing scale — 25 kg multi-layer kraft bags with an inner PE liner for production runs, and 5 kg aluminium foil bags for pilot and smaller orders.
  • Custom formats — custom packaging and private label are available; specify the intended format at enquiry so the correct salt form and grade are quoted.
  • Documentation — each batch ships with a CoA covering assay against the stated grade, heavy metals at NMT 10 ppm with lead at NMT 0.5 ppm, moisture and microbial limits.
Sports and pre-workout formats
Functional beverages and RTD
Clinical and medical nutrition
Capsule and tablet supplements
Powder blends and stick packs
Food fortification
Effervescent systems
Private-label and contract manufacture
Common nameL-Arginine
SynonymsArg; R; 2-Amino-5-guanidinopentanoic acid
CAS (free base)74-79-3
CAS (HCl salt)1119-34-2
Molecular formulaC₆H₁₄N₄O₂ (free base)
Molecular weight174.20 g/mol (free base); 210.66 g/mol (HCl)
AppearanceWhite crystalline powder, odourless
Assay (free base)≥99.5% (HPLC, USP/BP)
Assay (HCl salt)≥99.0% (HPLC, USP/BP)
Arginine content (HCl)~82.7% by weight (remainder HCl)
Specific rotation[α]D²⁰ = +26.9° to +27.9° (c=8, 6N HCl)
pH (5% aqueous, free base)10.5–12.0
SolubilityFree base: 15 g/100 mL at 20°C; HCl salt: highly soluble
Loss on dryingNMT 0.5% (free base); NMT 1.0% (HCl)
Residue on ignitionNMT 0.1%
Heavy metals (total)NMT 10 ppm
Lead / ArsenicNMT 0.5 ppm / NMT 0.5 ppm
Microbial limitsTPC NMT 10³ CFU/g; absence of Salmonella, E. coli
Source / productionBacterial fermentation; non-animal derived
Shelf life24 months (<25°C, cool, dry, sealed)
25 kg multi-layer kraft bags with inner PE liner
5 kg aluminium foil bags for pilot and smaller orders
Nitrogen-flushed, sealed for stability
Custom packaging and private label available
Quality Assurance

Fermentation-Derived. Pharmaceutical-Grade Purity. NO-Precursor Potency Guaranteed.

Every batch HPLC-assayed for ≥99.5% purity, specific rotation-confirmed for L-isomer identity, and tested for heavy metals, microbial limits, and residual solvents. Full USP/BP documentation with every shipment.

01

HPLC purity and isomer confirmation

Assay ≥99.5% (free base) by HPLC. Specific rotation [α]D²⁰ = +26.9° to +27.9° confirms pure L-isomer. Absence of D-arginine and related amino acid impurities verified. USP/BP COA with each batch.

02

Fermentation traceability

Bacterial fermentation (non-animal derived). Non-GMO certification available. Fermentation batch records provided. Free from TSE/BSE risk. Identity confirmed by IR spectroscopy and amino acid analysis.

03

Heavy metals and microbial safety

Lead NMT 0.5 ppm; Arsenic NMT 0.5 ppm; Mercury NMT 0.1 ppm; Cadmium NMT 0.2 ppm. TPC NMT 10³ CFU/g; absence of Salmonella, E. coli, Staph. aureus per USP methods.

04

Complete export documentation

COA, MSDS, Certificate of Origin; USP/BP analytical certificates; FSSAI compliance; Halal and Kosher on request; full traceability to fermentation batch. Digital documentation before shipment.

Formulation Intelligence

L-Arginine Buyer's Guide: Free Base vs HCl, Sports vs Clinical Applications & Citrulline Comparison

L-Arginine is one of the most studied amino acids with clinical evidence spanning cardiovascular medicine, sports performance, wound healing, and immunology. Selecting the right salt form, dose, and application context is critical to product efficacy and safety.

Free Base

L-Arginine Free Base ≥99.5%

CAS 74-79-3 · 100% arginine by weight · pH ~10.5

Alkaline in solution. Highest arginine content per gram — 100% vs 82.7% for HCl salt. Preferred for capsules, tablets, and powder blends where solubility is less critical. Lower cost per gram of active arginine, and the common specification in clinical nutrition and wound-care formats.

Best for: Capsules, tablets, powder blends, and clinical nutrition applications.
HCl Salt

L-Arginine HCl ≥99.0%

CAS 1119-34-2 · ~82.7% arginine by weight · neutral pH

Highly water-soluble, neutral-to-slightly acidic pH in solution. Preferred for beverages, ready-to-drink products, and effervescent tablets. Account for lower arginine content per gram when formulating: a 5g dose of arginine requires ~6g of arginine HCl. More stable in solution than free base at acidic pH.

Best for: RTD beverages, effervescent tablets, liquid supplements.
vs Citrulline

Arginine vs Citrulline for NO

Bioavailability and sports application comparison

L-Citrulline achieves higher plasma arginine levels than equivalent oral doses of L-Arginine, bypassing intestinal and hepatic arginase degradation. For sports performance and pump: citrulline (6–8g) or citrulline malate 2:1 is now the preferred NO precursor. L-arginine itself remains the common specification in clinical nutrition and wound-care formats.

Recommendation: Sports supplements → L-Citrulline; Clinical nutrition/wound healing → L-Arginine.
Safety Alert

Post-MI Contraindication

VINTAGE MI trial — contraindicated post-heart attack

Published safety literature advises against use in patients recently following myocardial infarction. Finished-product manufacturers should review the current safety literature and their market's requirements when defining the target population and any warnings on pack. This caution does not apply to healthy adults or other cardiovascular conditions (hypertension, endothelial dysfunction). Also: HSV reactivation risk at >6g/day in HSV-positive individuals.

Note: Balance with L-Lysine for HSV-positive subjects. Safe for healthy adults at 3–9g/day.
Buyer FAQ

Frequently Asked Questions

Free base at ≥99.5% for capsules, tablets and powder blends; the hydrochloride salt at ≥99.0% for beverages and ready-to-mix formats; a food grade at ≥98.5%; and a USP/BP compendial grade for clinical and medical use.
Where an aqueous system needs more arginine in solution than the free base can carry. The free base dissolves at 15 g/100 mL at 20°C; the HCl salt is markedly more soluble. Note the salt contributes chloride and has a different assay basis, so a weight-for-weight swap changes the delivered arginine content.
Assay against the stated grade, heavy metals at NMT 10 ppm with lead at NMT 0.5 ppm, moisture at NMT 0.5% for the free base or NMT 1.0% for the HCl salt, and microbial limits.
White crystalline powder at 40–80 mesh. Shelf life 24 months in cool, dry, sealed storage. Material ships nitrogen-flushed and sealed for stability.
Where a finished-product monograph or your own specification calls for a USP/BP reference — typically clinical and medical-nutrition formats. The food grade carries a lower assay floor and is specified where no compendial reference is needed.
The 40–80 mesh grade blends uniformly with common carriers and flows well in sachet and tub filling. For effervescent systems, specify the salt form at enquiry since the acid–base system interacts with the choice.
25 kg multi-layer kraft bags with an inner PE liner for production runs, and 5 kg aluminium foil bags for pilot and smaller orders. Custom packaging and private label are available.
Facility certification documents and the Certificate of Analysis for the batch. Halal and Kosher certificates are available on request. Material is made at GMP- and ISO-certified facilities.
Against your specification and volume. Salt form, grade and pack size all move the price, so state the intended format at enquiry.
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Supplied as a bulk ingredient for further manufacture. Buyers are responsible for compliance with the regulations of their destination market. This product is not intended to diagnose, treat, cure or prevent any disease.