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Quick Specs
CAS74-79-3 (free base)
Purity≥99.5% (free base); ≥99.0% (HCl)
SourceBacterial fermentation
Shelf life24 months
MOQ1 kg (sample); 25 kg (commercial)
Nutraceuticals

L-Arginine

Nitric Oxide Precursor Free Base & HCl Salt Fermentation-Derived CAS 74-79-3
The only amino acid that produces nitric oxide — the molecule behind vasodilation, cardiovascular protection, sports performance, and penile erection. L-Arginine is the foundational ingredient across cardiovascular medicine and sports nutrition.
L-Arginine's defining biochemistry is its role as the sole nitrogen donor for endothelial nitric oxide synthase (eNOS). The resulting nitric oxide (NO) molecule causes dose-dependent vasodilation, inhibits platelet aggregation, prevents LDL oxidation in the endothelium, and serves as the signal molecule for penile erection. This single biochemical pathway explains arginine's evidence across cardiovascular health, sports pump, erectile function, and wound healing.

SV Botanica supplies pharmaceutical-grade L-Arginine free base (≥99.5%, alkaline pH, ideal for tablets and capsules) and L-Arginine HCl (≥99.0%, highly water-soluble, ideal for beverages and RTD products) — both fermentation-derived, USP/BP compliant, GMP-certified.
Available specifications
    Quality Assurance

    Fermentation-Derived. Pharmaceutical-Grade Purity. NO-Precursor Potency Guaranteed.

    Every batch HPLC-assayed for ≥99.5% purity, specific rotation-confirmed for L-isomer identity, and tested for heavy metals, microbial limits, and residual solvents. Full USP/BP documentation with every shipment.

    01

    HPLC purity and isomer confirmation

    Assay ≥99.5% (free base) by HPLC. Specific rotation [α]D²⁰ = +26.9° to +27.9° confirms pure L-isomer. Absence of D-arginine and related amino acid impurities verified. USP/BP COA with each batch.

    02

    Fermentation traceability

    Bacterial fermentation (non-animal derived). Non-GMO certification available. Fermentation batch records provided. Free from TSE/BSE risk. Identity confirmed by IR spectroscopy and amino acid analysis.

    03

    Heavy metals and microbial safety

    Lead NMT 0.5 ppm; Arsenic NMT 0.5 ppm; Mercury NMT 0.1 ppm; Cadmium NMT 0.2 ppm. TPC NMT 10³ CFU/g; absence of Salmonella, E. coli, Staph. aureus per USP methods.

    04

    Complete export documentation

    COA, MSDS, Certificate of Origin; USP/BP analytical certificates; FSSAI compliance; Halal and Kosher on request; full traceability to fermentation batch. Digital documentation before shipment.

    Formulation Intelligence

    L-Arginine Buyer's Guide: Free Base vs HCl, Sports vs Clinical Applications & Citrulline Comparison

    L-Arginine is one of the most studied amino acids with clinical evidence spanning cardiovascular medicine, sports performance, wound healing, and immunology. Selecting the right salt form, dose, and application context is critical to product efficacy and safety.

    Free Base

    L-Arginine Free Base ≥99.5%

    CAS 74-79-3 · 100% arginine by weight · pH ~10.5

    Alkaline in solution. Highest arginine content per gram — 100% vs 82.7% for HCl salt. Preferred for capsules, tablets, and powder blends where solubility is less critical. Lower cost per gram of active arginine. Most clinical studies use free base. Standard for wound healing and clinical nutrition protocols.

    Best for: Capsules, tablets, powder blends, and clinical nutrition applications.
    HCl Salt

    L-Arginine HCl ≥99.0%

    CAS 1119-34-2 · ~82.7% arginine by weight · neutral pH

    Highly water-soluble, neutral-to-slightly acidic pH in solution. Preferred for beverages, ready-to-drink products, and effervescent tablets. Account for lower arginine content per gram when formulating: a 5g dose of arginine requires ~6g of arginine HCl. More stable in solution than free base at acidic pH.

    Best for: RTD beverages, effervescent tablets, liquid supplements.
    vs Citrulline

    Arginine vs Citrulline for NO

    Bioavailability and sports application comparison

    L-Citrulline achieves higher plasma arginine levels than equivalent oral doses of L-Arginine, bypassing intestinal and hepatic arginase degradation. For sports performance and pump: citrulline (6–8g) or citrulline malate 2:1 is now the preferred NO precursor. L-Arginine direct remains preferred in clinical nutrition, wound healing, and erectile function (pycnogenol combination evidence base).

    Recommendation: Sports supplements → L-Citrulline; Clinical nutrition/wound healing → L-Arginine.
    Safety Alert

    Post-MI Contraindication

    VINTAGE MI trial — contraindicated post-heart attack

    The VINTAGE MI trial (JAMA 2006) found significantly increased 6-month mortality in post-myocardial infarction patients taking L-Arginine 9g/day vs placebo. L-Arginine supplementation is contraindicated for ≥6 months post-MI. This safety signal does not apply to healthy adults or other cardiovascular conditions (hypertension, endothelial dysfunction). Also: HSV reactivation risk at >6g/day in HSV-positive individuals.

    Note: Balance with L-Lysine for HSV-positive subjects. Safe for healthy adults at 3–9g/day.
    Buyer FAQ

    Frequently Asked Questions

    L-Arginine is the sole substrate for endothelial nitric oxide synthase (eNOS), the enzyme that produces nitric oxide (NO) in blood vessel walls. NO diffuses into vascular smooth muscle and activates guanylate cyclase, producing cGMP, which relaxes smooth muscle and causes vasodilation. NO also inhibits platelet aggregation, reduces LDL oxidation, and prevents endothelial cell adhesion molecule expression. Meta-analyses confirm arginine supplementation reduces systolic blood pressure by 2–3 mmHg and improves flow-mediated dilation (FMD) — the gold-standard endothelial function test.
    L-Arginine free base (MW 174.20): alkaline pH in solution (~pH 10.5), 100% arginine content by weight. L-Arginine HCl (MW 210.66): acidic pH in solution, ~82.7% arginine content by weight, highly water-soluble, better for liquid formulations and RTD beverages. For capsules and tablets with high arginine dose targets, free base is preferred. For beverages and RTD products, HCl salt is preferred for solubility. Formulators must adjust dose based on molecular weight difference when switching between forms.
    Sports performance: 3–8g L-Arginine or L-Citrulline 30–60 minutes pre-workout. Many formulators now prefer L-Citrulline for pump effects due to higher oral bioavailability. Cardiovascular health: 3–6g/day in divided doses. Erectile function: 3–6g/day best evidence in combination with 80mg pycnogenol. Wound healing: 9–17g/day in clinical protocols. L-Arginine has a short half-life; split dosing improves sustained NO production.
    Yes, and for most sports applications citrulline is now preferred over arginine alone. L-Citrulline bypasses first-pass intestinal and hepatic arginase metabolism, reaching the kidney where it is converted to arginine — yielding higher plasma arginine and NO than equivalent doses of oral arginine. For supplement formulations targeting muscle pump and endurance performance, L-Citrulline 6–8g or Citrulline Malate 2:1 is the preferred NO precursor ingredient. L-Arginine direct is still preferred in clinical nutrition and wound healing protocols.
    L-Arginine is generally safe at supplemental doses (3–9g/day) in healthy adults. Key contraindications: (1) Post-MI — the VINTAGE MI trial found increased mortality in post-MI patients supplementing arginine; contraindicated within 6 months of MI; (2) Herpes simplex virus reactivation — arginine is a required replication nutrient for HSV; >6g/day may trigger outbreaks in HSV-positive individuals; balance with lysine; (3) Nitrate medications — additive hypotension risk; (4) Arginase excess states (sepsis, trauma) reduce efficacy — citrulline may be more effective.
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