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Quick Specs
CAS56-12-2
Purity≥99.0%
SourceFermentation or synthetic
Shelf life24 months
MOQ1 kg (sample); 25 kg (commercial)
Nutraceuticals

GABA (Gamma-Aminobutyric Acid)

Inhibitory Neurotransmitter Fermentation & Synthetic Grade Sleep & Anxiety CAS 56-12-2
The brain's primary off-switch — GABA quiets overactive neural circuits, reducing anxiety, improving sleep, and lowering blood pressure through GABA-A chloride channel activation and peripheral receptor mechanisms.
GABA occupies 30–40% of all CNS synapses, making it the dominant inhibitory signal in the brain. When overstimulation occurs — anxiety, insomnia, hypertension — GABA deficiency is frequently implicated. Commercial supplementation has long been questioned due to blood-brain barrier concerns, but multiple clinical mechanisms are now established: oral-pharyngeal absorption, peripheral vagal GABA receptors, and gut-brain GABA signalling all contribute to documented anxiolytic and sleep-improving effects at 100–300mg doses.

SV Botanica supplies fermentation-derived GABA (Lactobacillus hilgardii, supporting natural label claims) and synthetic GABA — both ≥99% purity, GMP-certified, with full traceability.
Available specifications
    Quality Assurance

    Fermentation-Derived. HPLC-Verified ≥99% Purity.

    Every batch tested by HPLC for ≥99% assay, heavy metals, microbial limits, and identity confirmation. Fermentation-grade supports natural label claims. Full documentation with every shipment.

    01

    HPLC purity verification

    Assay ≥99.0% by HPLC. Identity confirmed by IR spectroscopy and melting point (200°C). Related amino acid impurities profiled. Both fermentation and synthetic grades meet identical analytical specifications.

    02

    Fermentation source documentation

    Lactobacillus hilgardii fermentation source. Non-animal, non-GMO. Fermentation batch records provided. Supports natural origin label claims. TSE/BSE-free. Identity confirmed by amino acid analysis.

    03

    Heavy metals and microbial safety

    Lead NMT 0.5 ppm; Arsenic NMT 0.5 ppm; Mercury NMT 0.1 ppm. TPC NMT 10³ CFU/g; absence of Salmonella, E. coli per USP/EP methods. Residual solvent testing on synthetic grade.

    04

    Export documentation

    Full COA, MSDS, Certificate of Origin. FSSAI compliance for food applications. Halal/Kosher certificates on request. Fermentation batch documentation for natural label substantiation. Digital delivery before shipment.

    Formulation Intelligence

    GABA Buyer's Guide: Fermentation vs Synthetic, Dose Ranges & Application Targets

    GABA serves three distinct market segments with very different dose requirements: sleep/anxiety supplements (100–300mg), blood pressure functional foods (10–20mg nattoGABA-type), and sports GH-stimulation formulations (3–5g). Selecting the wrong dose for the application is the most common formulation error.

    Fermentation Grade

    Natural GABA ≥99%

    Lactobacillus hilgardii · Natural label claim

    Produced by bacterial fermentation — L-glutamic acid converted to GABA by glutamate decarboxylase. Supports "natural GABA" or "fermentation-derived" label claims. Identical molecular structure to synthetic. Priced higher. Equivalent of branded PharmaGABA-type fermentation products. Preferred for premium natural-positioned sleep, anxiety, and functional food products.

    Best for: Premium natural supplements, functional foods, Japan-style nattoGABA blood pressure products.
    Synthetic Grade

    Synthetic GABA ≥99%

    Chemical synthesis · Cost-effective · No natural claim

    Identical molecule, same pharmacological activity. Cannot support "natural" label claims. Significantly lower cost — suited for sports supplements, high-dose GH-stimulation formulas (3–5g/serving), and cost-sensitive mainstream formulations. Same HPLC purity specification. No safety or efficacy disadvantage vs fermentation grade at equivalent purity.

    Best for: Sports recovery, GH-stimulation stacks, cost-optimised mainstream supplements.
    Dose Guide

    Three Dose Tiers

    10mg · 100–300mg · 3–5g — very different applications

    10–20mg/day: blood pressure (Japanese functional food nattoGABA level). 100–300mg: anxiety reduction and sleep — the most common supplement dose range. Clinical data from RCTs confirms sleep latency reduction and anxiety biomarker reduction. 3–5g post-exercise: GH stimulation for sports recovery and lean mass formulations. Specify clearly by application — a 3g serving is 30× the anxiety/sleep dose.

    Note: Taste masking required at doses above 500mg — GABA has a mild bitter note.
    Stack Synergies

    Key Combinations

    L-Theanine · Magnesium · Melatonin · 5-HTP

    GABA + L-Theanine (100mg + 200mg): best-evidenced sleep combination — increases non-REM sleep and reduces sleep latency more than either alone. GABA + Magnesium glycinate: synergistic CNS inhibitory effect for anxiety and sleep. GABA + 5-HTP: complementary mechanisms — GABA reduces cortical excitability; 5-HTP increases serotonin/melatonin for deep sleep. Avoid combining GABA with alcohol, benzodiazepines, or other CNS depressants at high doses.

    Signature blend: 100mg GABA + 200mg L-theanine + 200mg magnesium glycinate for sleep support.
    Buyer FAQ

    Frequently Asked Questions

    This has been debated extensively. Early studies suggested GABA cannot cross an intact blood-brain barrier (BBB) due to its charged nature. However, recent evidence supports meaningful central effects via multiple mechanisms: (1) absorption through the oral mucosa and pharynx, bypassing the BBB; (2) peripheral GABA-A/B receptors on the vagus nerve, transmitting inhibitory signals centrally; (3) enteric nervous system GABA receptors modulating gut-brain signalling. Multiple human RCTs confirm measurable reductions in anxiety biomarkers and EEG alpha-wave enhancement at 100–300mg doses, establishing functional efficacy regardless of the mechanistic debate.
    Fermentation GABA: produced by Lactobacillus hilgardii converting glutamic acid to GABA via glutamate decarboxylase. Supports 'natural' label claims. Identical molecular structure to synthetic. Priced higher. Synthetic GABA: identical molecule; lower cost; suitable for all supplement applications but cannot claim 'natural' origin. Both achieve ≥99% purity. For premium natural-positioned products: fermentation grade. For cost-sensitive mainstream formulations: synthetic grade.
    Sleep: 100–300mg 30 minutes before bed. Studies show significant reduction in sleep latency and improvement in sleep quality. Best evidence at 300mg. Synergistic combination: 100mg GABA + 200mg L-theanine. Anxiety/stress: 100mg acutely (before stressful events); 200–400mg daily for chronic stress. Blood pressure: 10–20mg/day nattoGABA-type (Japanese functional food level). Growth hormone stimulation: 3–5g immediately post-exercise. Note: the sleep/anxiety doses (100–300mg) are far below the GH-stimulating dose (3g).
    GABA is GRAS in the US at supplement doses up to 3g/day. No significant adverse effects at 100mg–3g/day in human clinical trials. Formulation considerations: (1) highly water-soluble — excellent for beverages; (2) stable in powder form; (3) slightly bitter taste — requires masking at doses >500mg; (4) compatible with L-theanine, magnesium, melatonin in sleep formulations; (5) avoid combining with benzodiazepines or alcohol at high doses.
    Yes — specifically via growth hormone stimulation. A clinical study found 3g oral GABA immediately before exercise increased post-exercise plasma GH by 400% vs placebo. A 2015 study found 12 weeks of GABA (3g/day) combined with resistance training increased lean mass significantly more than resistance training alone. The mechanism: GABA stimulates pituitary somatotroph cells via GABA-A/B receptors to release GH. For sports recovery, the target dose is 3–5g post-workout; for anxiety/sleep, 100–300mg is sufficient.
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