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Quick Specs
CAS56-12-2
Purity≥99.0%
SourceFermentation or synthetic
Shelf life24 months
MOQ1 kg (sample); 25 kg (commercial)
Nutraceuticals

GABA (Gamma-Aminobutyric Acid)

Inhibitory Neurotransmitter Fermentation & Synthetic Grade Relaxation & Sleep Formats CAS 56-12-2
A non-protein amino acid supplied at ≥99.0% by fermentation or synthesis, for relaxation, sleep and functional-beverage formulations. CAS 56-12-2.
GABA occupies 30–40% of all CNS synapses, making it the dominant inhibitory signal in the brain. It is formulated into relaxation, sleep and functional-beverage products, where the permitted claim position is set by the destination market. Oral bioavailability and blood-brain-barrier permeability remain actively discussed in the literature; formulators should assess the evidence base for their own claim position.

SV Botanica supplies fermentation-derived GABA (Lactobacillus hilgardii, supporting natural label claims) and synthetic GABA — both ≥99% purity, made at GMP-certified facilities, with full traceability.
Available specifications
Fermentation GABA ≥99%
Natural label claim — Lactobacillus derived
Synthetic GABA ≥99%
Chemical synthesis — cost-effective grade
Premium fermentation grade
Higher-specification fermentation material
Instant Powder / Granule
For functional beverages and powder blends
  • Relaxation and stress-support formulations — commonly formulated at 100–200 mg per serving, often alongside L-theanine or magnesium. Claim wording is market-specific: the EU has no authorised health claim for GABA, so EU-bound formulations should be positioned on composition rather than on effect.
  • Sleep and night-time formulations — used in capsules, powders and functional beverages at 100–300 mg per serving, frequently combined with L-theanine, glycine or botanical extracts. Confirm the permitted claim set for the destination market before finalising label copy.
  • Functional beverages and RTD — the instant/granular grade disperses without clouding at typical beverage inclusion levels; solubility is 130 g/100 mL at 20°C, so it carries easily in aqueous systems.
  • Japanese and East Asian markets — GABA has a long regulatory and consumer history in Japan, including use in FOSHU-notified products. Requirements differ by market; buyers should confirm the current position with their regulatory adviser.
  • Natural label positioning — the fermentation-derived grade supports a 'naturally fermented' or 'non-synthetic' descriptor where the destination market permits it. The synthetic grade is chemically identical and is generally specified where cost governs.
  • Sports and recovery formulations — used in post-exercise and night-time recovery blends. Inclusion levels vary widely by format; we quote against your specification.
  • Powder blends and stick packs — the 40–80 mesh grade blends uniformly with common carriers and flows well in sachet filling. The slightly bitter taste profile usually requires masking in unflavoured systems.
  • Documentation — each batch ships with a CoA covering assay by HPLC, heavy metals (NMT 10 ppm, lead NMT 0.5 ppm), moisture (NMT 0.5%) and microbial limits, plus a manufacturing-route declaration for label substantiation.
Relaxation and stress-support supplements
Sleep and night-time formulations
Japanese-style functional food formats
Sports and post-exercise recovery formats
Focus and cognitive-category supplements
Functional beverages and adaptogen blends
Stick packs and powder blends
Mood-category and gut-health formulations
Common nameGABA (Gamma-Aminobutyric Acid)
Synonymsγ-Aminobutyric acid; 4-Aminobutyric acid; Piperidic acid
CAS number56-12-2
Molecular formulaC₄H₉NO₂
Molecular weight103.12 g/mol
AppearanceWhite crystalline powder, odourless, slightly bitter
Assay≥99.0% (HPLC or potentiometric titration)
Melting point200°C (decomposes)
Solubility in water130 g/100 mL at 20°C (highly soluble)
pH (10% aqueous solution)6.5–7.5
Specific rotationOptically inactive (achiral molecule)
Loss on dryingNMT 0.5%
Residue on ignitionNMT 0.1%
Heavy metals (total)NMT 10 ppm
Lead / ArsenicNMT 0.5 ppm / NMT 0.5 ppm
Microbial limitsTPC NMT 10³ CFU/g; absence of Salmonella, E. coli
Production methodFermentation (Lactobacillus hilgardii) or chemical synthesis
Natural label supportFermentation grade only
Regulatory statusGRAS in USA; approved food ingredient in Japan; supplement in EU/India
Shelf life24 months (<25°C, cool, dry, sealed)
25 kg multi-layer kraft bags with inner PE liner
5 kg aluminium foil bags for smaller orders
Moisture-proof sealed packaging
Custom packaging and private label available
Quality Assurance

Fermentation-Derived. HPLC-Verified ≥99% Purity.

Every batch tested by HPLC for ≥99% assay, heavy metals, microbial limits, and identity confirmation. Fermentation-grade supports natural label claims. Full documentation with every shipment.

01

HPLC purity verification

Assay ≥99.0% by HPLC. Identity confirmed by IR spectroscopy and melting point (200°C). Related amino acid impurities profiled. Both fermentation and synthetic grades meet identical analytical specifications.

02

Fermentation source documentation

Lactobacillus hilgardii fermentation source. Non-animal, non-GMO. Fermentation batch records provided. Supports natural origin label claims. TSE/BSE-free. Identity confirmed by amino acid analysis.

03

Heavy metals and microbial safety

Lead NMT 0.5 ppm; Arsenic NMT 0.5 ppm; Mercury NMT 0.1 ppm. TPC NMT 10³ CFU/g; absence of Salmonella, E. coli per USP/EP methods. Residual solvent testing on synthetic grade.

04

Export documentation

Full COA, MSDS, Certificate of Origin. FSSAI compliance for food applications. Halal/Kosher certificates on request. Fermentation batch documentation for natural label substantiation. Digital delivery before shipment.

Formulation Intelligence

GABA Buyer's Guide: Fermentation vs Synthetic, Dose Ranges & Application Targets

GABA serves three distinct market segments with very different dose requirements: relaxation and sleep formats (100–300 mg), Japanese-style functional food formats (10–20 mg), and sports recovery formats (3–5 g). Selecting the wrong dose for the application is the most common formulation error.

Fermentation Grade

Natural GABA ≥99%

Lactobacillus hilgardii · Natural label claim

Produced by bacterial fermentation — L-glutamic acid converted to GABA by glutamate decarboxylase. Supports "natural GABA" or "fermentation-derived" label claims. Identical molecular structure to synthetic. Priced higher. Comparable to other premium fermentation-derived material. Specified for natural-positioned relaxation, sleep and functional food products.

Best for: Premium natural supplements, functional foods, Japan-style nattoGABA blood pressure products.
Synthetic Grade

Synthetic GABA ≥99%

Chemical synthesis · Cost-effective · No natural claim

Identical molecule and specification. Cannot support "natural" label claims. Lower cost — suited for sports supplements, high-dose formats (3–5 g/serving), and cost-sensitive mainstream formulations. Same HPLC purity specification. No safety or efficacy disadvantage vs fermentation grade at equivalent purity.

Best for: Sports recovery formats, high-dose stacks, cost-optimised mainstream supplements.
Dose Guide

Three Dose Tiers

10mg · 100–300mg · 3–5g — very different applications

Inclusion levels differ sharply by product format: roughly 10–20 mg per serving in Japanese functional-food style products, 100–300 mg in relaxation and sleep formats, and 3–5 g in sports recovery formats. Specify the intended format on enquiry — a 3 g serving is around 30× a 100 mg one, and the two are not interchangeable on cost or on label position.

Note: Taste masking required at doses above 500mg — GABA has a mild bitter note.
Stack Synergies

Key Combinations

L-Theanine · Magnesium · Melatonin · 5-HTP

GABA + L-Theanine (100mg + 200mg): best-evidenced sleep combination — increases non-REM sleep and reduces sleep latency more than either alone. GABA + magnesium glycinate: a common pairing in relaxation and sleep formats. GABA + 5-HTP: complementary mechanisms — GABA reduces cortical excitability; 5-HTP increases serotonin/melatonin for deep sleep. Avoid combining GABA with alcohol, benzodiazepines, or other CNS depressants at high doses.

Signature blend: 100mg GABA + 200mg L-theanine + 200mg magnesium glycinate for sleep support.
Buyer FAQ

Frequently Asked Questions

Fermentation-derived GABA at ≥99.0% (produced by Lactobacillus fermentation of glutamic acid, supporting a natural label claim), synthetic GABA at ≥99.0%, a higher-specification fermentation material, and an instant powder/granule grade for functional beverages and powder blends. All grades are pharmaceutical or food grade.
They are the same molecule and both reach ≥99.0% purity. The difference is production route and label positioning: the fermentation grade supports a 'naturally fermented' or 'non-synthetic' descriptor where the destination market permits it, and is priced higher; the synthetic grade is generally specified where cost governs. Each batch carries a manufacturing-route declaration for label substantiation.
Assay by HPLC against the ≥99.0% specification, heavy metals at NMT 10 ppm with lead at NMT 0.5 ppm, moisture at NMT 0.5%, and microbial limits. Batch documentation and the manufacturing-route declaration ship with every consignment.
White crystalline powder, odourless, with a slightly bitter taste. Particle size 40–80 mesh. Solubility 130 g/100 mL in water at 20°C. Moisture NMT 0.5%. Shelf life 24 months in cool, dry, sealed storage.
Solubility of 130 g/100 mL at 20°C makes it straightforward to carry in aqueous systems, and the instant/granule grade is intended for functional beverages and powder blends. The 40–80 mesh grade blends uniformly with common carriers and flows well in sachet filling. The slightly bitter profile usually requires masking in unflavoured systems.
Permitted claims differ by market and are the finished-product manufacturer's responsibility. The EU maintains no authorised health claim for GABA, so EU-bound formulations are normally positioned on composition. Japan has a longer regulatory and consumer history for the ingredient, including FOSHU-notified products. Confirm the current position for your destination market with your regulatory adviser.
25 kg multi-layer kraft bags with an inner PE liner, and 5 kg aluminium foil bags for smaller orders. All packaging is moisture-proof and sealed. Custom packaging and private label are available.
Facility certification documents, the Certificate of Analysis for the batch, and the manufacturing-route declaration. Halal and Kosher certificates are available on request. Material is made at GMP- and ISO-certified facilities.
Inclusion levels vary by format and by the claim position taken in the destination market; relaxation and sleep formats commonly sit in the 100–300 mg per serving range. Pricing, minimum order quantity and lead time are quoted against your specification and volume.
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Supplied as a bulk ingredient for further manufacture. Buyers are responsible for compliance with the regulations of their destination market. This product is not intended to diagnose, treat, cure or prevent any disease.