| Common name | Fisetin |
| IUPAC name | 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4-one |
| Synonyms | 3,3',4',7-Tetrahydroxyflavone; Fisetol; Fustet |
| CAS number | 528-48-3 |
| Molecular formula | C₁₅H₁₀O₆ |
| Molecular weight | 286.24 g/mol |
| Appearance | Orange-yellow to brownish-yellow fine crystalline powder |
| Assay (HPLC) | ≥98.0% fisetin (aglycone basis) |
| Natural source | Strawberry (Fragaria × ananassa) fruit; Rhus succedanea wood/fruit |
| Solubility | Practically insoluble in water (<0.01 mg/mL); soluble in DMSO (>20 mg/mL), ethanol (~1 mg/mL); improves with phytosome complexation |
| Melting point | 330°C (decomposes) |
| pH (1% suspension) | 4.5–6.5 |
| Moisture content | NMT 2.0% |
| Heavy metals | NMT 10 ppm total; Lead NMT 0.5 ppm; Arsenic NMT 0.5 ppm |
| Pesticide residues | Complies with EU Regulation 396/2005 MRLs |
| Microbial limits | Total aerobic count NMT 10³ CFU/g; Absence of Salmonella, E. coli |
| Key related compound | Fustin (3,3',4',7-tetrahydroxyflavanonol) — identified and reported separately on COA |
| Shelf life | 24 months in original sealed packaging |
| Storage | Below 25°C, protected from light (photosensitive pigment); avoid humidity above 60% RH |
| Packaging | Nitrogen-flushed opaque aluminium foil bags — light-protected, moisture barrier |
Fisetin purity is confirmed by HPLC with specific quantification of fisetin aglycone — not total flavonoid content. Batch testing includes absence of fustin (the primary related compound), heavy metals, and microbial safety to GMP pharmacopoeia standards.
COA reports specific fisetin aglycone content. Fustin (the 3-deoxyfisetin precursor in Rhus wood) is identified and reported separately as an impurity. Minimum 98% fisetin confirmed on every batch.
Fisetin's orange-yellow chromophore is photosensitive. Opaque, nitrogen-flushed aluminium packaging preserves both colour and bioactivity throughout storage and international transit.
Botanical-source fisetin is tested for lead, mercury, arsenic, cadmium, ochratoxin A, and aflatoxins where applicable. Synthetic/semi-synthetic grades tested for residual solvents (ICH Q3C).
COA, MSDS, Certificate of Origin, and Phytosanitary Certificate with every shipment. Halal and Kosher certificates on request. Full digital documentation before dispatch.
No natural compound has generated as much longevity science interest per dollar of consumer awareness as fisetin. Found in strawberries at microgram-per-gram levels, the idea that you would need to eat 37 strawberries per day to get a 100mg supplement dose helps consumers understand why concentrated bulk fisetin exists. Grade, pigment stability and documentation are the practical considerations for formulators building scientifically credible products.
Fisetin is supplied at ≥98% by HPLC as the primary commercial grade and at ≥95% as a standard botanical extract grade. Selection between them is normally driven by the assay window your finished-product specification allows and by cost.
Natural fisetin content — Strawberry 160 µg/g; Apple 26 µg/g; Persimmon 11 µg/g; Onion 5 µg/g; Cucumber 0.1 µg/g. At 160 µg/g, a 100mg supplement dose requires approximately 625g of strawberries. This communication point resonates with consumers and validates the need for concentrated supplemental fisetin. Commercial extraction comes from Rhus succedanea wax tree fruits or semi-synthesis.
Formats in this category vary between daily dosing (100–200mg) and intermittent high-dose "pulse" approaches (500–1,000mg for 2 consecutive days monthly). Inclusion levels and dosing schedule are set by the finished-product formulator. Use the pulse protocol. Inclusion levels are set by the finished-product formulator.
A pre-blended dual-flavonol grade combining fisetin and quercetin at a specified ratio, supplied where a formulator wants the ratio fixed upstream rather than blending in-house. Both are practically insoluble in water, so the same dispersion routes apotently; quercetin adds mast cell stabilisation and COMT inhibition. From a formulation standpoint, both flavonoids have poor oral bioavailability that can be addressed through phytosome complexation or fat co-ingestion.
Supplied as a bulk ingredient for further manufacture. Buyers are responsible for compliance with the regulations of their destination market. This product is not intended to diagnose, treat, cure or prevent any disease.
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